The 2018 world wheat (Triticum spp.) production is estimated at 730 million tonnes. Canada is the sixth largest producer of wheat in the world with estimated production of 31.5 million tonnes in 2018. Wheat contributed $9 billion dollars to the Canadian economy in 2018. Other than durum, 80% of the wheat produced belongs to the premium quality Canada Western Red Spring class. Canada exported approximately 20.5 million tonnes of wheat to 66 countries, which is 14% of the total world wheat exports, contributing approximately $5 billion dollars to the Canadian economy. In 2017, spring hexaploid wheat accounted for 69% of the total wheat production followed by durum wheat (23%) and winter wheat (8%). Approximately 98% of the wheat is grown in the prairie provinces of Alberta (39%), Saskatchewan (41%) and Manitoba (18%). The Eastern, Western and Northern Prairies vary in their growing conditions and hence the breeding programs focus on region specific issues such as biotic stress, abiotic stress and early maturing genotypes for the three regions respectively. The key challenges for Canadian wheat breeding programs are to pyramid resistance for major wheat diseases such as Fusarium head blight (FHB), and rusts. Orange Wheat Blossom Midge and Wheat Stem Sawfly are insect problems in the Canadian Prairies. To make significant genetic gains, combat the unpredictable climate and evolving pathogen pressure, breeding efforts must evolve to integrate traditional breeding tools with advances in genomics, phenomics, big data and artificial intelligence. Availability of multiple “Omics”, gene function and manipulation, computing and data analysis tools can now assist breeders to make informed decisions, from selecting the right parents for crossing to developing field ready cultivars. The poster will discuss some of the advances in plant science and their potential use in wheat breeding for the Canadian Prairies.