Wheat is an important staple crop in Ethiopia cultivated mainly by small scale farmers. The Ethiopian highlands are suitable for wheat production as well as for perpetuation of several pathogens. Stripe rust caused by Puccinia striiformis f.sp. tritici (Pst) is the most important disease of wheat in the high altitudes. Bimodal rainfall distribution, low night temperatures and different planting dates all favour Pst development. The fungus commonly infects leaves and leaf sheath, however spike infections are common in the high altitudes. More than 80 bread wheat varieties were released for production since 2000; however, most of them succumbed to new races of Pst. Recurrent stripe rust epidemics have been reported in major wheat producing areas of Ethiopia in the last three decades. However, the 1988 epidemics on Dashen (Yr9) and the 2010epidemics on Kubsa (Yr27) were the most devastating of all, resulting in 60-100% yield loss in hotspot areas. The incursion of race PstS11(AF2012) in 2016 threatened several of the popular varieties in major wheat growing areas. As part of an integrated control strategy, CIMMYT with national and international partners engaged in developing and fast track seed multiplication of wheat varieties with Adult Plant Resistance (APR) to rust diseases. However, some of these varieties require at least one critical fungicide application depending on the onset of the diseases in hot spot areas. CIMMYT is also working with partners in capacity building, awareness raising, pathogen surveillance and early warning, which have assisted nationwide fungicide contingency planning. In this paper, the authors highlight previous achievements and discuss future interventions for the management of stripe rust diseases in Ethiopia.