Wild relatives of common wheat are rich sources for Fusarium head blight (FHB) resistance, among which Aegilops tauschii L. (synonym Ae. squarrosa), the D genome progenitor of common wheat (AABBDD). In order to utilize the resistance genes in Ae. tauschii, primary synthetic hexaploid wheat (SHW) was developed by hybridizing durum wheat (Triticum turgidum L. ssp. durum, 2n = 4x= 28, genome AABB) and Ae. Tauschii (2n = 2x = 14, genome DD). Durum wheat accessions used were mainly elite breeding lines from the CIMMYT breeding program, and the primary SHWs were usually crossed with common wheat lines to generate SHW derivatives, which have better agronomical traits than their SHW ancestors do. In the current study, 443primary SHW lines were screened for FHB resistance under greenhouse conditions, with two experiments done in 2016 and one in 2017. Inoculation took place at the anthesis stage by injecting 20 µl of inoculum at 70,000 spores/ml into a floret of a middle spikelet. Inoculated spikes were bagged for two days and evaluated at 21 days after inoculation. A wide range of FHB severity has been observed, with the lowest being 5.4% (averaged over three experiments, where the resistant check Sumai3 being 5.0%), the highest being 83.4% (where the susceptible check Falcin# being 46.2%),and the grand mean being 34.6%. Genotyping of the panel is ongoing to identify resistance QTL via genomewide association mapping approaches.