Cadmium (Cd) and mycotoxins are both worrying contaminants that threaten the safety of food products derived from cereal kernels. Indeed, a recent French total diet survey showed that deoxynivalenol (DON) and Cd human exposure through food mainly results from the consumption of cereal-derived products. Durum wheat, in particular, is the most sensitive for Cd and DON accumulation in grains. Cd is a trace element naturally occurring or added to soils by natural and industrial atmospheric deposition, or through agricultural inputs. It is readily absorbed by wheat roots and translocated to grains. Cereal contaminations with DON, in Europe, are mainly caused by the toxigenic filamentous fungus Fusarium graminearum that develops on growing crops. Respective levels of Cd and DON in commercialized wheat grains for human consumption are strictly regulated in Europe and legislation fixed DON concentrations under the limit of 1750 µg/Kg and those of Cd under 0.2 mg/kg. The possible occurrence of both contaminants is also puzzling for human health and is under study in a 4 year project called CaDON. Different durum wheat grain samples displaying contrasting levels of contaminants were analysed in this study. Cd distribution through distinct processing will be presented and compared with those of DON.