Plant bZIP transcription factors have been shown to participate in multiple stress responses. In the present study, we identified a gene in wheat induced by multiple abiotic stresses, TabZIP15, which encodes a bZIP protein. Three highly homologous sequences of TabZIP15 were isolated from the A 、B and D genome of hexaploid wheat. The TabZIP15 protein was shown to localize to the nucleus and Inhibit transcription in yeast. A detailed characterization of transgenic plants overexpressing the TabZIP15 gene revealed that the TabZIP15 protein could improve tolerance to multiple stresses in Arabidopsis and wheat. These results indicate that the TabZIP15 protein plays an important role in plant stress tolerance and that modification of the expression of this protein may improve abiotic stress tolerance in crop plants.