Wheat transformation can be a highly efficient process, and its application is no longer limited by a small pool of amenable germplasm. Using the PureWheat system, we have transformed over 40 bread wheat varieties, including winter and spring types, durum wheat and those with specific disease susceptibilities. This increases the relevance of this technology to agriculture, and is crucial for disease resistance studies. It also enables new technologies such as gene editing to be applied to the elite germplasm of choice directly, without the need for lengthy back-crossing. We have successfully implemented CRISPR/Cas9 editing in hexaploid wheat. The use of a highly efficient transformation system also facilitates transfer of complex traits or multi-gene pathways to wheat. Our recent results in these areas will be described.