A.E. Watkins collection is the best representated wheat landrace diversity panel, comprising 827 accessions from 32 countries, which was assembled in the 1920-30s before systematic plant breeding had been implemented in the countries of origin. The Watkins collection was initially hosted by the University of Cambridge followed by the Plant Breeding Institute and now the John Innes Centre, which instigated an extensive effort over the past decades in genotyping, phenotyping both for the entire natural population and a huge dataset of experimental mapping populations across UK, it is also distributed globally in Egypt, Australia, Mexico (CIMMYT) and China to investigate a wide range of agronomic traits to enable gene discovery and breeding. Combining the datasets in whole-genome sequencing, wheat genetic variation maps and high-throughput phenotyping, we revealed a broad spectrum of beneficial alleles underlying 166 traits, the potential genetic value of which were further assessed by backcrossing and targeted pre-breeding. Our study links the genotypes and phenotypes systematically, unraveling the mechanistic dilemma in genetic breeding caused mostly by historical geography in its global spread and trait antagonism in physioloigical trade-off, which further enables us an opportunity to retrace and reconfigure the “Green Revolution” by establishing a successful bridge for the injection of this newly identified beneficial diversity into modern wheat breeding. The study of A.E. Watkins open a new door of Wheat Genomics-design Breeding. In this workshop, we will include 2 sessions, 12 speakers in total from our WatkinsG2B (Watkins Genomics to Breeding) consortium, and include presentations ranging across pre-breeding strategies, genotyping and new wheat array designing, wheat genomics big data and bioinformatics development, QTL and mapping populations, phenotyping, and pre-breeding.