For over 50 years the Global Wheat Program at the International Maize and Wheat Improvement Center (CIMMYT) has developed and delivered improved wheat germplasm globally. The impacts of global breeding have been well documented and CIMMYT remains one of the largest providers of publicly available spring, durum, and winter wheat germplasm. Increasing climate threats, a requirement to reduce inputs, and the rapidly changing geo-political landscape all present significant challenges to the future of global wheat. At the same time there are also new opportunities to integrate tools and technologies and to work across disciplines to drive new potential. This talk will summarize recent work at CIMMYT to accelerate future wheat improvement, to build greater resilience and to respond to changing and expanding threats to wheat stability.