Zinc is an essential micronutrient for plants as it plays an important role in the synthesis of various biomolecules, acts as a cofactor in many enzymes, and plays an important role in hormone action. Zinc oxide nanoparticles (ZnO NP) are less toxic, comparatively inexpensive, and biocompatible compared with other metal oxide nanoparticles because zinc does not interact with the majority of pharmaceutically active molecules. In today's climate change scenarios, crops are exposed more frequently to episodes of abiotic stresses. These stresses limit crop production to various extents for example it is estimated that drought and salinity may cause a 50% loss in crop production. In recent years nanobiotechnology is gaining momentum in terms of mitigating the constraints associated with abiotic stresses. Keeping in view the above facts the present investigation was aimed to find the best concentration and time of ZnO NP priming on wheat under salinity and drought stress. Seed of wheat cultivar HD 2009 was soaked in ZnO NP of different concentrations ranging from 10 ppm to 1,000 ppm for two-time intervals 12 hr and 24 hr. The soaked seeds were hydroponically grown under three conditions salinity 6 dsm-1, drought created by 8.27% PEG 6000, and water as the control in a completely randomized design respectively for 15 days. Root length; shoot length, fresh weight of root, shoot, and dry weight of root and shoot were taken to study the effect of ZnO NP, the concentration of NP, and time of priming. The positive effect of ZnO NP in terms of increased shoot length, root length, and fresh and dry weight of root and shoot were observed at 500 ppm and 12 hr of treatment as compared to control also the positive effect was more in drought as compared to salinity. Results received were validated in net house experiment.