Drought has negative effects on cereal production. Studies have shown that many basic leucine zipper transcription factors (bZIP TFs) help to cope with drought stress. In this study, bZIP TF wheat (Triticum aestivum L.) FD-Like2 (TaFDL2) was isolated and functionally analyzed. Three homologs of TaFDL2 were identified and their expression was induced by drought and abscisic acid (ABA) treatment. TaFDL2-1A has transactivation activity and two activation domains, and the domain D region has different effects on the transcriptional activity of the two domains. Analysis of TaFDL2-1A overexpression plants indicated their enhanced drought tolerance and greater sensitivity to ABA. TabZIP8-7A was identified as a protein that interacts with TaFDL2-1A in the nucleus, and the overexpression of TabZIP8-7A conferred greater drought resistance and ABA sensitivity in Arabidopsis. Surprisingly, TaFDL2-1A×TabZIP8-7A double overexpression lines exhibited the highest drought resistance. Genetic and transcriptional regulation analyses demonstrated that stress-response gene transcription was initiated by TaFDL2-1A or TabZIP8-7A via the ABA signaling pathway. Importantly, TaFDL2-1A and TabZIP8-7A synergistically promoted ABA-inducible gene expression in a more efficient manner to form the transcriptional activation complex. Our findings provide new insights into the molecular mechanisms that allow bZIP TFs to regulate ABA signaling in response to drought stress.